Best Creatine for GLP-1 Users

If there's one supplement that every GLP-1 user should seriously consider, it's creatine monohydrate. The evidence is unusually strong: decades of research show creatine helps preserve lean muscle mass during caloric restriction — exactly the situation GLP-1 medications create.

Creatine works by increasing phosphocreatine stores in muscles, which improves the energy available for muscle contractions and supports muscle protein synthesis. During the significant caloric deficit induced by Ozempic, Wegovy, or Mounjaro, this energy support helps prevent the muscle breakdown that would otherwise occur.

The dose is simple: 3–5g daily, no loading phase needed, taken consistently. There's no meaningful difference between expensive 'advanced' creatine formulations and basic creatine monohydrate — the research is done on monohydrate, and it's the most cost-effective option by far.