Multivitamins
With 20–39% fewer calories consumed, micronutrient gaps are nearly inevitable on GLP-1 therapy. Vitamin D, B12, iron, zinc, and magnesium are the most commonly deficient. A quality multivitamin isn't a performance supplement here — it's a nutritional safety net that addresses the gaps your reduced appetite creates.
How we chose these products
Every product in this category is assigned an evidence tier — Strong, Moderate, or Emerging— based on the clinical research behind the key ingredient category. Products labeled “GLP-1 Specifically Labeled” are formulated or marketed directly for GLP-1 medication users.
Our composite score weights evidence tier, Amazon rating, and review volume. Products are sorted by composite score by default. We earn affiliate commissions on purchases, which does not influence our ratings.
What to look for
Prioritize multivitamins that include meaningful doses of the nutrients most depleted on GLP-1 therapy: Vitamin D3 (2000–5000 IU), B12 (500–1000mcg), iron (if female), zinc (15–25mg), and magnesium (200–400mg). Many one-a-day tablets contain inadequate amounts of these key nutrients.
Vitamin D3 deserves special attention: research suggests it may increase GLP-1 receptor expression by up to 9-fold, potentially enhancing the medication's effectiveness. Most GLP-1 users are already D-deficient before starting therapy.
If nausea is an issue, gummy multivitamins or capsules taken with food are better tolerated than large tablets. Take multivitamins with your largest meal to maximize absorption and minimize digestive discomfort.
Top picks — 27 products
Shaklee
Vita-Lea Women Multivitamin
GLP-1 LabeledAlso available in Men's formula (Vita-Lea Men)
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Shaklee
Vita-Lea Men Multivitamin
GLP-1 LabeledAlso available in Women's formula (Vita-Lea Women)
Vimerson Health
Multivitamin for Women with Methylated Vitamins and Chelated Minerals for Energy
Also available in a Men's multivitamin formula
Vimerson Health
Multivitamin for Men with Methylated Vitamins and Chelated Minerals for Energy
Also available in: 60 Liquid Capsules format
Sanar Naturals
Sanar Naturals Collagen Pills for Women & Men | Hydrolyzed Peptides with Vitamin E & Vitamin C | Supports Hair
Garden of Life
Garden of Life Organics Multivitamin for Women - Women's Once Daily Multi - Whole Food Multi with Iron
Other useful categories for GLP-1 users
Frequently asked questions
Do I really need a multivitamin on Ozempic or Wegovy?
Most clinical nutritionists recommend multivitamin supplementation for GLP-1 users. With appetite reduced by 20–39%, it becomes very difficult to obtain adequate micronutrients from food alone. Vitamin D, B12, iron, zinc, and magnesium deficiencies are particularly common and can cause fatigue, hair loss, and muscle weakness.
What vitamins are most deficient on GLP-1 medications?
The most commonly deficient micronutrients on GLP-1 therapy are: Vitamin D3 (often deficient even before starting), B12 (reduced meat intake is common), iron (particularly in menstruating women), zinc (reduced in caloric restriction), and magnesium (depleted with reduced food intake and diuresis).
Can vitamin D improve how well Ozempic or Wegovy works?
Emerging research suggests Vitamin D3 supplementation may increase GLP-1 receptor expression by up to 9-fold, potentially enhancing your medication's effectiveness. While this research is preliminary, the case for adequate Vitamin D is strong regardless — most GLP-1 users are deficient.
Should I take a GLP-1-specific multivitamin or a regular one?
GLP-1-specific multivitamins are formulated with higher doses of the nutrients most depleted on GLP-1 therapy. Whether branded as 'GLP-1 support' or not, look for meaningful doses of D3, B12, zinc, and magnesium rather than just the minimum RDA amounts.