Best Fiber Supplement for Ozempic Constipation

Constipation is one of the most common GLP-1 side effects — affecting up to 50% of Ozempic users, particularly in the early months of treatment. The mechanism is straightforward: Ozempic slows gastric emptying as part of how it works, and reduced food volume means less bulk to stimulate bowel movements.

For most users, constipation on Ozempic is manageable with the right fiber supplement and adequate hydration. The evidence is clear: psyllium husk (the active ingredient in Metamucil) has the strongest clinical research behind it of any fiber supplement. It forms a gel in the intestine that softens stool, increases bulk, and stimulates peristalsis — the muscle contractions that move things along.

These are the fiber and gut health products we recommend for Ozempic users, ranked by evidence quality and practical usability.